In Long COVID, oxidative stress may be driven by: persistent immune activation mitochondrial dysfunction mast cell activation (MCAS) chronic inflammation autonomic nervous system dysregulation psychological stress (PTSD, illness trauma) Even everyday factors can worsen the burden: travel overexertion poor sleep emotional stress Supporting the Body Against Oxidative Stress While research is ongoing, strategies that may help reduce oxidative stress include: Foundational Support Anti-inflammatory nutrition Adequate hydration Sleep optimization Stress reduction Nervous System Regulation Breathwork Pacing strategies Reducing overstimulation Nutritional & Clinical Considerations Antioxidant support (as clinically appropriate) Mitochondrial support Addressing histamine and MCAS if present Always consult with a qualified provider before starting new treatments or supplements

A survey of the US Clinical Trial registry threw up multiple studies involving phytonutrients and other dietary interventions, which have been completed as part of Phase I and II studies
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Sadjadi R, Sullivan S, Grant N, Thomas SE, Doyle M, Hammond C, Duong R, Corre C, David W, Eichler F (2020) Clinical myopathy in patients with nephropathic cystinosis