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GI side effects were generally mild to moderate and most pronounced during the dose escalation phase
This places any initial nausea during sleeping hours and the early part of the week, when motivation and routine tend to be strongest
Supportive secondary endpoints included change from baseline to week 26 in FPG, 7-point SMPG, body weight (%), BMI, waist circumference and fasting lipid profile
Modulation of human intestinal microbiota in a clinical trial by consumption of a -d-glucan-enriched extract obtained from Lentinula edodes
These symptoms are typically most pronounced during initial weeks of therapy and can be minimised through gradual dose titration starting at the lowest available dose
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