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Under a high-fat diet background, the SHF group was somewhat separated from the HFD group, suggesting that semaglutide intervention could improve the composition of gut microbiota in obese mice (Figure 5B)

They also reduce hepatic glucose output by decreasing hepatic FFA uptake and the expression of key gluconeogenesis enzymes such as PEPCK and G6Pase, while promoting hepatic sensitivity to insulin, transforming the liver from an "energy output organ" to an "energy storage organ"

doi: 10.1124/jpet.108.148643, 219