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Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
Protein boosters (whey, plant-based, or collagen) bring the protein content into the 20-gram-plus range that medical guidelines recommend
Following perfusion, the brain was fixed for 48 hours and embedded in paraffin
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