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Rybelsus is not recommended in children and adolescents under 18 years as the safety and efficacy in this age group have not yet been studied

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Temporary S-glutathionylation of enzymes in the TCA cycle, ETC, or -oxidation pathway protects them from irreversible oxidation when ROS is high but may also hypothetically serve as a mechanism to diminish mitochondrial ROS production by reducing their activity [51]