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Lowering blood glucose levels is the basis of diabetes treatment, not only in terms of preventing microvascular complications, including CKD, but also in preventing cardiovascular events

3.1.2 Semaglutide: mechanistic endpoints and effect amplification in combination therapy Evidence for semaglutide tends to focus on mechanistic and tissue-distribution endpoints

Sorensen M, Sanz A, Gmez J, Pamplona R, Portero-Otn M, Gredilla R, Barja G: Effects of fasting on oxidative stress in rat liver mitochondria

Both GLP1-RAs and SGLT2is contribute to weight loss through different mechanisms

In vitro treatment with NR helps maintain mitochondrial membrane potential, decreases oxidative stress, and stabilizes chromosomal structure [360]