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MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation

Starting at 2 mg and escalating slowly is KEY, as the Phase 2 data showed a lower starting dose of 2 mg produced meaningfully fewer GI side effects than jumping in at 4 mg

Harrach et al., 2013)

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When MTHF loses its methyl group, tetrahydrofolate (THF) is formed