The introduction of GLP-1 therapeutics has revolutionized the treatment of type 2 diabetes and obesity, with other potential indications under investigation
These strategies are grounded in the energy envelope theory, whose conceptual foundation is the maintenance of a balance between activity and rest to prevent energy depletion
45,46 Increasingly, more studies have shown that G6PD activity is increased in several types of cancers, including bladder, breast, prostate, gastric cancers compared with normal tissues, and the high expression of G6PD predicts poor clinical outcome in various cancer patients and plays critical roles in tumorigenesis and chemoresistance
The medication prescribed directly determines the ceiling of what is achievable
Author contributions SD, ZS, KJ, and RD: conceptualization