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The Bioavailability Breakthrough: Liposomal Delivery To address the issues of absorption and stomach discomfort, researchers developed liposomal delivery
Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
This method allows for higher concentrations of glutathione to enter the bloodstream, maximizing its antioxidant effects and detoxification potential
Primarily used for liver support, it also aids in detoxification processes and enhances immune function
The biodistribution of NP4-Cy7.5 was investigated using IVIS
