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Deletion of hepatocyte-specific DPP4 in these aged mice did not affect glucose tolerance as only whole-body deletion of DPP4 increased systemic active GLP-1 and led to reduced blood glucose excursion during oral glucose tolerance test (Supplemental Figure 3, A and B), consistent with previous work (22, 23)

The real risk here is that big improvements in overall health and appearance can distract from a progressive joint disease thats quietly getting worse in the background

These reports might be one reason Amazon removed the products, but Amazon never confirmed this

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