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GLP-1 is also produced by pancreatic -cells and neurons in the nucleus of the solitary tract

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Daniel Bessesen, chief endocrinologist at the University of Colorado School of Medicine, May 6, 2026 Biomolecules, Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss, March 13, 2025 BMJ, Weight regain after cessation of medication for weight management: systematic review and meta-analysis, Jan

On the other hand, long periods of inactivity can slow gut motility, which may contribute to constipation