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Research by Khorram et al

The results

Patients who are using skin lightening products or undergoing other skin lightening treatments should refrain from exposing themselves as best they can throughout the duration of treatment to avoid risking skin damage, including skin cancer

A nearly 25% average weight reduction in less than a year is unprecedented in the published literature

Berberine inhibits neuronal apoptosis by regulating autophagy-related proteins [Microtubule-associated protein 1A/1B-light chain 3 (LC3), Beclin-1, p62], and apoptosis regulatory proteins [caspase 3, caspase 8, caspase 9, poly ADP-ribose polymerase (PARP), and B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X (Bax)] (Zhang et al., 2016)