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Essential documentation elements include: Confirmed diagnosis of type 2 diabetes mellitus with supporting evidence (HbA1c results, glucose monitoring data) Detailed description of neuropathic symptoms, including location, character, severity, and temporal pattern Findings from neurological examination, particularly sensory testing using 10-g monofilament, vibration perception (128-Hz tuning fork), and ankle reflexes Specification of neuropathy type (e.g., distal symmetric polyneuropathy, autonomic neuropathy, mononeuropathy) Foot risk stratification according to NICE NG19 criteria (low risk, moderate risk, high risk, active diabetic foot problem) Results from diagnostic investigations such as nerve conduction studies when performed for atypical or uncertain cases Documentation of any functional impairment or complications arising from neuropathy Clinicians should avoid vague terminology such as 'possible neuropathy' or 'neuropathic symptoms' without clear diagnostic confirmation

Stability data indicates Matrixyl degrades in highly acidic or alkaline formulations, so researchers should maintain pH 57 for optimal peptide integrity

doi:10.1007/s00394-020-02233-0