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These agents modulate neurotransmission, reduce neuroinflammation and oxidative stress, enhance mitochondrial and neurotrophic function, and improve insulin sensitivity and hypothalamic-pituitary-adrenal (HPA) axis regulation

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Ultimately, surgical interventions with autologous epidermal grafts may be used but these result in weak and thin skin with nearly a 35% failure rate (Reddy et al., 2014

Clinical research shows that this combination can lead to significant and sustainable weight loss, often exceeding what is achievable through diet and exercise alone

Understanding their limitations prevents disappointment and dangerous self-management decisions