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PubMed PMID: 33645410

It is a non-hormonal approach: no IGF-1 or cortisol changes, no stimulant jitters, no appetite suppression

However, it can be legally prescribed for wellness and recovery off-label through licensed U.S

The peptide may also strengthen the internal organs and repair IBD-related damage

Sirtuins, poly(ADP-ribose) polymerases and the CD38/CD157 ectoenzymes cleave the glycosidic bond between the nicotinamide and the ADP-ribosyl moiety, releasing nicotinamide stoichiometrically, so NAD+ is destroyed rather than recycled and must be resynthesised through the NAMPT-limited salvage pathway (Cant, Menzies and Auwerx, Cell Metabolism, 2015)