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PTPN22 (short for protein tyrosine phosphatase non-receptor type 22), known as a risk factor in multiple autoimmune disorders, reduces T-cell activity by removing phosphate groups from phosphorylated proteins such as LCK, Fyn, and Zap70, which are associated with T-cell receptor signaling pathway
Habener, J F (1986-09)
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The advancement of incretin-based therapeutics has resulted in a sea change in the management of type 2 diabetes, with the most recently developed agents promoting notable reductions in weight as well 6,7,8
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