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Clinical recommendations to manage gastrointestinal adverse events in patients treated with glp-1 receptor agonists: a multidisciplinary expert consensus

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Like obstructions of the small intestine, an untreated blockage in the bowel could lead to tissue death, peritonitis, or sepsis

In SUSTAIN-6, in adults with type 2 diabetes at high cardiovascular risk, semaglutide reduced the same composite to 6.6% versus 8.9% (hazard ratio 0.74, about a 26% relative reduction)

Berberine studies show high variability in individual response