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A placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis
K.JiangY
While oral administration peaks at approximately 220-300 micromoles per liter due to intestinal transport saturation, vitamin C injections can achieve concentrations exceeding 15,000 micromoles per literrepresenting a 70-fold increase over oral bioavailability
Total weekly dose averages ~5 mg, consistent with research protocols [3] [4]
In a phase II trial, CagriSema reduced body weight by an average of 15.6% after 32 weeks, achieving a comparable efficacy to Tirzepatide
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