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Once inside the mitochondrial matrix, these fatty acids undergo beta-oxidation, a process that chops them into smaller acetyl-CoA molecules

When used with insulin or sulfonylureas, they may increase the risk of hypoglycaemia, and dose adjustments of these medications may be necessary

The medication carries a risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

The mechanism involves protecting neuronal mitochondria from oxidative stress while supporting neurotransmitter synthesis pathways

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