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Others require adjustments over several months to optimize outcomes

Serious Side Effects (Both Medications) Both medications carry small risks of pancreatitis, gallbladder problems, and kidney issues (usually from dehydration)

However, significant limitations exist in the current evidence: Most human data comes from small studies, with limited randomised controlled trials specifically designed to assess alcohol consumption The mechanisms by which GLP-1 medications might reduce alcohol intake are not fully understood Individual responses vary considerably, and not all patients experience changes in drinking behaviour Long-term effects and safety of using these medications specifically for alcohol reduction remain unknown The MHRA has not approved GLP-1 receptor agonists for alcohol use disorder, and these medications should not be considered a treatment for problematic drinking

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Vitamin B12 (cyanocobalamin or methylcobalamin ) is light-sensitive and can degrade when exposed to UV or fluorescent light