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It regulates immune signaling, nutrient absorption, hormone release, and interactions with the trillions of microbes that make up the human microbiome

Experimental studies in animal models indicate that IL-1 acts upstream of other proinflammatory cytokines, as the administration of an IL-1 receptor antagonist not only attenuates neurodegeneration but also significantly reduces TNF- and IFN- protein levels in the mesencephalon [195]

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Cortisol elevation from stress promotes fat storage, particularly around the midsection