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The new GLP-1 RA users, SGLT-2 inhibitor users and DPP-4 inhibitor users were defined as a first-time redemption for prescription of drugs with anatomical therapeutic chemical (ATC) codes A10BJ (GLP-1), A10BH (DPP-4 inhibitors) or A10BK (SGLT-2 inhibitors)

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PPO mice model was established by feeding with high-fat diet for 16 weeks, and then injected with semaglutide (30 nmol/kg -1 d -1 , sc.) for 22 days before pregnancy