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Although most of the residues in those regions were identical or very similar between MRP1 and MRP2, synonymous mutations or difference in the choice of codons can result in serious protein misfolding 48

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When B12 levels are low, the signs can be varied: Anemia: fatigue, weakness, pale skin, and dizziness Fatigue: a deep-seated weariness that doesn't improve with rest Nerve Damage: tingling or numbness in hands and feet, balance problems, and memory loss (seek medical advice promptly) Mood Disturbances: depression, irritability, and personality changes While our bodies can store B12 for years, some groups are more susceptible to deficiency, often because of absorption issues rather than diet