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Areas that respond to anti wrinkle injections Forehead lines horizontal lines from raising the brows Frown lines (glabella) vertical lines between the brows from frowning Crows feet radiating lines at the outer corners of the eyes Bunny lines diagonal lines on the upper nose from scrunching Brow lift selective injection to subtly elevate the lateral brow Gummy smile reducing excessive gum show when smiling Lip flip subtle eversion of the upper lip border Chin dimpling (peau dorange) smoothing the mentalis muscle Marionette lines / downturned mouth corners softening DAO muscle activity Neck banding softening prominent platysmal bands Masseter / jaw slimming separate dedicated treatment Axillary hyperhidrosis separate dedicated treatment Chronic migraine separate dedicated treatment What anti wrinkle injections cannot do Lift sagging skin addressed by surgical procedures (facelift, blepharoplasty) or skin-tightening modalities Restore lost facial volume addressed by dermal fillers or fat grafting Improve skin texture, pigmentation, or tone addressed by laser, peels, or biostimulators Remove deep static wrinkles fully these need filler or resurfacing alongside A consultation with the plastic surgeon establishes which problems are present and which treatment, or combination of treatments, is most appropriate

doi: 10.1523/JNEUROSCI.0529-11.2011 36 MakinS