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Upon ligand binding, the receptor undergoes a conformational change that activates intracellular signalling pathways, primarily through the cyclic adenosine monophosphate (cAMP) second messenger system
There were also no effects of GLP-1 or liraglutide on plasma insulin levels, which were similarly elevated in saline- and drug-treated db/db mice
By modulating these pathways, GLP-1 agonists seem to dampen cravings and reduce the reinforcing effects of addictive substances. ( The unexpected health benefits of Ozempic and Moujaro .) But the effects on dopamine signaling may not be the whole story, experts say
Cell Mol Life Sci 2000
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