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With respect to the previously mentioned study, this proof-of concept study has important methodological strengths residing in the availability of baseline and post-treatment hepatic biopsies
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[42] reported that insulin resistance induced by 5 days of HCHF feeding (as assessed by HOMA-IR) also increased the expression of various macrophage markers (for example cluster of differentiation CD68, CD14 and CD11c) in skeletal muscle and reduced the markers of insulin signalling (solute carrier family transporter SLC2A and glycogen synthase-1)
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