Potential Benefits of a Weekly B12 Schedule It is important to be clear up front: these benefits apply mainly to people who are actually low in B12
Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40, 43,44,45,46,47,48,49,50]
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The temperature in the door fluctuates more, which is less stable for sensitive research materials
But for most purposes (like weekly maintenance injections), IM is the preferred route at home because its simpler (the vitamins absorb quickly from muscle into the bloodstream over a few hours)