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no such increase occurred in KO mice (Fig

All use is strictly in vitro and for research purposes only

These approaches enable precise delivery of nucleic acid cargo (siRNA, miRNA, plasmids encoding non-coding RNAs, etc.) to injured renal tissue, allowing modulation of transcriptional networks, silencing of pathogenic genes, and reprogramming of cellular metabolism and inflammatory responses.Platelet membranemimicking nanoparticles (PMVs@PLGA) carrying TGF-1 siRNA utilize the natural homing ability of platelet membranes to damaged vasculature, selectively silencing the TGF-1/Smad3 pathway, reducing collagen deposition and inflammatory cytokine release in UUO and IRI models, and avoiding systemic off-target effects [98]

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HIV Clin Trials