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In contrast, FOXO4-DRI leverages the elevated expression of FOXO4 and P53 in senescent cells by specifically blocking the interaction between FOXO4 and P53 to promote apoptosis via the P53 signaling pathway (Tao et al., 2016
Severe dehydration may increase the risk of acute kidney injury
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These features enable the design of nanocarriers that remain stable in circulation but rapidly release their payloads upon reaching the tumor site, maximizing therapeutic efficacy while minimizing off-target toxicity
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