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Gastrointestinal events (nausea, vomiting, diarrhea) were the dominant adverse-event class, dose-dependent and mostly mild-to-moderate
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Clinical need: Is there a legitimate reason to compound this substance
The data was not pooled because there were only two studies for plasma and two for serum with data in a suitable form to combine
Common side effects may include: Nausea: Especially after meals or following a dose increase Vomiting: Triggered by persistent or severe nausea Constipation: Due to slower digestion and reduced food intake Diarrhea: Including loose stools or changes in bowel habits Bloating: Caused by delayed stomach emptying Abdominal discomfort: Such as mild cramping, pressure, or digestive upset Tips to manage GLP-1 side effects Reduce portion sizes Many patients find that eating smaller meals helps reduce nausea and digestive discomfort
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