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Therapeutic targeting of mitochondrial metabolic dependencies CRC cells sustain a high metabolic state and therapeutic resistance by activating multiple mitochondrial pathways, including the TCA cycle, OXPHOS, FAO, and one-carbon metabolism [18]
5 Ongoing research and future therapy Current guidelines and medications for the management of DCM are based on treating T2DM and HF separately, as there is no medication indicated specifically for the treatment of DCM
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Most patients notice initial weight loss within 2-4 weeks
Tirzepatide is associated with lower risk of joint pain across multiple sites, including low back pain, hip pain, and knee pain, with particularly strong benefits for knee pain (HR 0.84)
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