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However, while clinical trials of RAASi have shown consistent benefits in reducing mortality and heart failure hospitalizations in patients with HFrEF, evidence supporting their use in heart failure with preserved ejection fraction (HFpEF) and heart failure with mildly reduced ejection fraction (HFmrEF) is more variable
It is proposed that the beneficial effects of acetylcarnitine include the supply of activated acyl groups for the acylation of membrane phospholipids
The cardiovascular benefits of GLP-1 receptor agonists are thought to result from multiple mechanisms, including weight reduction, improved glycaemic control, blood pressure lowering, and potential direct cardioprotective effects
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