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A Skeptical Take of Semaglutide for Cardiac Protection A preventive cardiologist offers a critical appraisal of the SELECT trial of Semaglutide (Wegovy) When the New England Journal of Medicine published the placebo-controlled SELECT trial of semaglutide in patients with established vascular disease, I had thought cardiology had discovered another disease-modifying drug

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This substantial caloric deficit, while necessary for weight loss, can result in decreased energy availability for daily activities

Lissoni P, Tancini G, Barni S, Paolorossi F, Ardizzoia A, Conti A, Maestroni G

Having metabolic syndrome is defined as meeting at least three of the five criteria 3