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The Harmony Outcomes trial further revealed that albiglutide reduced MACE by 22% over a median follow-up period of 1.6 years in patients with type 2 diabetes and cardiovascular disease ( p = 0.0006) [70]

Dysbiosis impairs the intestinal barrier, increasing its permeability and allowing bacteria and lipopolysaccharides (LPS) from the gut to translocate into the systemic circulation, leading to systemic inflammation (148)

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Neither is FDA-approved for weight loss, but the FDA has approved Wegovy, another Novo Nordisk semaglutide product, for chronic weight management