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doi: 10.1016/j.neubiorev.2024.105756
This was markedly longer than in the other CVOTs where the median follow-up ranged from 1.3 to 3.8 years and perhaps suggesting enrollment of predominantly low-risk patients in REWIND as a possible limitation
The biological rationale for the combination rests on mechanistic complementarity
The GIP activation appears to buffer gastrointestinal distress rather than compound it, which bodes well for real-world adherence
While these findings are biologically plausible, they should be interpreted with caution and considered hypothesis-generating rather than confirmatory
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