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Tell your doctor if you gain more than 10 pounds or more than 2 pounds a day for 3 days in a row

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Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)

Nat Commun 8:75 Hu D, Sheng Z, Zhang P, Yang D, Liu S, Gong P, Gao D, Fang S, Ma Y, Cai L (2013) Hybrid gold-gadolinium nanoclusters for tumor-targeted NIRF/CT/MRI triple-modal imaging in vivo

Serum immune markers and transition to psychosis in individuals at clinical high risk