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AMG 133 (now known as maridebart cafraglutide) is an optimized GIPR/GLP-1R bispecific molecule engineered by conjugating a fully human monoclonal anti-human GIPR-Ab with two GLP-1 analogue agonist peptides using amino acid linkers
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Increased BBB permeability suggests loss of BBB integrity evidenced by EC degeneration, TJs decrease, and pericyte deterioration and detachment from ECs
16 weeks (2x daily, 5-on/2-off) 7 vials 160 doses needed
As the field shifts toward disease-modifying and regenerative approaches such as siRNA, monoclonal antibodies, and stem cell-derived islets, advanced humanized mouse models have become essential for improving translational accuracy and accelerating progress
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