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M1 macrophages are involved in antitumor immunity, whereas M2 macrophages promote tumor growth, metastasis, and immune suppression

In addition, G6PD has a critical role, along with NFKB-inducing kinase (NIK), in supporting metabolism in activated T cells (56)

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It reverses the effects of L-arginine (the NO precursor) and L-NAME (the NO blocker)

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