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This distinction is particularly useful in experimental designs where separation of adipose-specific signaling from systemic endocrine effects is required
Contraindications for B12 injections are few but key
Pathological causes of elevated B12 warrant careful consideration: Haematological disorders : Myeloproliferative neoplasms (polycythaemia vera, chronic myeloid leukaemia), acute leukaemia, and lymphoproliferative disorders can increase B12-binding proteins (transcobalamin and haptocorrin), elevating total serum B12 [3] Liver disease : Hepatocellular damage releases stored B12 into circulation
American College of Obstetricians and Gynecologists (ACOG)
B12 injections have many benefits and are often prescribed for deficiencies that cause fatigue, shortness of breath, diarrhea, numbness and neurological damage
