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Alexis Granite, MD, is a board-certified dermatologist in America and England

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Research dose/evidence: Some cosmetic studies show Acmella extract (the source of spilanthol) improves wrinkle appearance, but there are fewer large clinical trials than for retinoids or peptides (there never are with botanical extracts)

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Expert Insight / Pro Tip When working with complex multi-peptide blends like this 12mg formulation, temperature stability during reconstitution is vital