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Moreover, after 32 weeks of treatment, CagriSema demonstrated a numerically greater improvement in glycemic control, achieving a 2.2%-point reduction in HbA1c levels, compared to 0.9%-points with cagrilintide and 1.8%-points with semaglutide monotherapy [124]

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Potential Long-Term Risks Although AOD-9604 does not increase IGF-1 levels, there are concerns about its long-term metabolic effects, including: Unknown impact on fat metabolism regulation Since AOD-9604 alters fat-burning pathways, researchers are still investigating whether prolonged use could affect natural fat metabolism

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The statistical model was considered valid when the PLS-DA model (Figure S4A) adopted the criteria for success of R 2 0.7 and Q 2 0.4 [42], which was observed (Figure S4B)