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At the same time, it slows down the rate at which food leaves the stomach and reduces appetite by acting on appetite centers in the brain

When a GLP-1 receptor agonist activates those receptors, it produces a modest but measurable increase in resting heart rate

Thus, while the hypothalamus may play a role, it is likely not the primary locus of action mediating the anorectic effects of GLP-1 and GLP-1 derivatives

Even at low doses, these medications carry risks including pancreatitis (requiring discontinuation if suspected), gallbladder disease, and rare but serious adverse events such as medullary thyroid carcinoma (boxed warning

Under certain circumstances, health insurance companies may cover the cost of a prescription drug that they normally dont cover