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The physiological response to exogenous testosterone is further modulated by individual genetic variability, particularly polymorphisms of the androgen receptor gene, which contribute to substantial interindividual differences in efficacy and adverse effect profiles ( The principal mechanisms of action of testosterone include: stimulation of protein synthesis and anabolic pathways, direct activation of androgen receptors in target tissues, psychological effects, such as alterations in mood, motivation, and libido

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A single injection of P5 or Ex4 (1 g kg 1 ) significantly improved glucose clearance in response to the glucose challenge as indicated by a significant decrease in the AUC of GTT when compared with control

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