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[1] Administration: 1 mg/kg i.v. a single dose for 5 min [1] Rat: SHRs and WKY male 20-week-old weighing 300-350 g [4] Administration: 2 mg/kg i.p. daily for 2 weeks [4] [1]

209 Schaffer AguzzoliC.FerreiraP

PMID 16214343

Early stages of plaque development involve endothelial activation induced by inflammatory cytokines, oxidized low-density lipoprotein, and/or changes in endothelial shear stress.6 Several studies have investigated the antioxidant effect of melatonin on low-density lipoprotein oxidation

A recent study reported that exosomes derived from mouse bone marrow MSCs exerted similar cardio-protective effects [248]