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Infante-Rivard C, Jacques L

Abstract Cerebral ischemia reperfusion (I/R) is one of the neurovascular diseases which leads to severe brain deterioration

Protein S -glutathionylation is an important post-translation modification, providing protection of protein cysteines from irreversible oxidation and, at the same time, serving to transduce a redox signal by changing structure/function of the target protein

There are no published Phase II or III controlled clinical trials that establish a safe dose, dosing interval, or adverse-event profile for these routes

The non-standard residues in its sequence (Aib, D-2-Nal, D-Phe) confer metabolic stability against peptidase degradation and constrain the bioactive conformation