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The RS is transmitted to the nucleus to promote the up-regulation of defense genes, such as SA biosynthesis genes, and down-regulation of PhANGs , ultimately leading to the synthesis of SA and the output of basic immunity, further strengthening the active inhibition of photosynthesis and the accumulation of ROS, and finally causing cell death and disease resistance (Fig

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If exogenous ochronosis is present on the skin, multiple sessions of chemical peels and laser treatment for hyperpigmentation (Q-switched NDYAG) would be needed in addition to the skincare products and IV antioxidant therapies