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The reviewer is an independent U.S.-licensed clinician

Rather than overriding pain signals, this model works to identify and address the root causes of chronic pain such as chronic inflammation, tissue injury, biomechanical imbalance, nutrient depletion, metabolic dysfunction, gut-immune disruption, or nervous system sensitization

Clin Ther 39:1780-1789.e33

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While the first clinical trial of PF-05231023 demonstrated a decrease in markers of bone formation and an increase in markers of bone resorption, this was accompanied by a significant reduction in body weight