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NNMT expression has been found to be elevated in white adipose tissue and correlates with obesity and metabolic dysfunction in various studies

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This review paper highlights the influence of cellular energy metabolism on fat burning, emphasizing therapies that target cellular energy dynamics as promising targets for obesity

Lipolysis Enhancement and Lipogenesis Inhibition In obese Zucker rats, daily oral administration of AOD9604 significantly increased lipolytic activity in adipose tissue compared to controls, establishing direct adipocyte-level lipolysis stimulation as a key mechanism of action in pre-clinical models

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