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The crossover study (Parsons et al., 2012) reported that at 12 hours after a single instillation, 50% of patients reported a successful response to the active instillation with a 42% reduction in pain but only 13% reported a successful response to the placebo instillation accompanied by a 21% reduction in pain

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In Canada, synthetic injectable peptides are generally regulated as prescription drugs under the Food and Drugs Act, and Health Canada has issued public advisories (April 2026 and earlier) cautioning that unauthorized injectable peptide products are illegal regardless of whether they are labelled 'for research use only.' Research-grade AOD-9604 supplied by Koipeptides is intended for in vitro laboratory study only and is not authorized for any human or veterinary application