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Accompanied by neurologic symptoms such as leg weakness, numbness, bowel or bladder dysfunction, or saddle anesthesiathese are red flags for cauda equina syndrome or severe nerve compression requiring emergency evaluation

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Published human trials report minimal adverse events at doses ranging from 50mg to 100mg daily over 12 weeks, with the most common findings being mild gastrointestinal discomfort (812% of participants) and transient headache (57%)

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